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504 plan for children with food allergies

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504 plan for children with food allergies
DESCRIPTION
Zafirlukast is a synthetic, selective peptide leukotriene receptor antagonist(LTRA), with the chemical name 4-(5-cyclopentyloxy-carbonylamino-1-methyl-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide 504 plan for children with food allergies. The molecular weight of zafirlukast is 575.7 and the structural formula is:

The empirical formula is: C 31 H 33 N 3 O 6 S

Zafirlukast, a fine white to pale yellow amorphous powder, is practically insolublein water 504 plan for children with food allergies. It is slightly soluble in methanol and freely soluble in tetrahydrofuran,dimethylsulfoxide, and acetone 504 plan for children with food allergies.

ACCOLATE is supplied as 10 and 20 mg tablets for oral administration 504 plan for children with food allergies.

Inactive Ingredients: Film-coated tablets containing croscarmellose sodium,lactose, magnesium stearate, microcrystalline cellulose, povidone, hypromellose,and titanium dioxide 504 plan for children with food allergies.

CLINICAL PHARMACOLOGY
Mechanism of Action
Zafirlukast is a selective and competitive receptor antagonist of leukotrieneD 4 and E 4 (LTD 4 and LTE 4 ), components of slow-reacting substance of anaphylaxis(SRSA) 504 plan for children with food allergies. Cysteinyl leukotriene production and receptor occupation have been correlatedwith the pathophysiology of asthma, including airway edema, smooth muscle constriction,and altered cellular activity associated with the inflammatory process, whichcontribute to the signs and symptoms of asthma 504 plan for children with food allergies. Patients with asthma were foundin one study to be 25-100 times more sensitive to the bronchoconstricting activityof inhaled LTD 4 than nonasthmatic subjects 504 plan for children with food allergies.

In vitro studies demonstrated that zafirlukast antagonized the contractileactivity of three leukotrienes (LTC 4 , LTD 4 and LTE 4 ) in conducting airwaysmooth muscle from laboratory animals and humans 504 plan for children with food allergies. Zafirlukast prevented intradermalLTD 4 -induced increases in cutaneous vascular permeability and inhibited inhaledLTD 4 -induced influx of eosinophils into animal lungs 504 plan for children with food allergies. Inhalational challengestudies in sensitized sheep showed that zafirlukast suppressed the airway responsesto antigen; this included both the early- and late-phase response and the nonspecifichyperresponsiveness 504 plan for children with food allergies.

In humans, zafirlukast inhibited bronchoconstriction caused by several kindsof inhalational challenges 504 plan for children with food allergies. Pretreatment with single oral doses of zafirlukastinhibited the bronchoconstriction caused by sulfur dioxide and cold air in patientswith asthma 504 plan for children with food allergies. Pretreatment with single doses of zafirlukast attenuated the early-and late-phase reaction caused by inhalation of various antigens such as grass,cat dander, ragweed, and mixed antigens in patients with asthma 504 plan for children with food allergies. Zafirlukastalso attenuated the increase in bronchial hyperresponsiveness to inhaled histaminethat followed inhaled allergen challenge 504 plan for children with food allergies.

Clinical Pharmacokinetics and Bioavailability:
Absorption
Zafirlukast is rapidly absorbed following oral administration 504 plan for children with food allergies. Peak plasma concentrationsare generally achieved 3 hours after oral administration 504 plan for children with food allergies. The absolute bioavailabilityof zafirlukast is unknown 504 plan for children with food allergies. In two separate studies, one using a high fat andthe other a high protein meal, administration of zafirlukast with food reducedthe mean bioavailability by approximately 40% 504 plan for children with food allergies.

Distribution
Zafirlukast is more than 99% bound to plasma proteins, predominantly albumin 504 plan for children with food allergies. The degree of binding was independent of concentration in the clinically relevantrange 504 plan for children with food allergies. The apparent steady-state volume of distribution (V SS /F) is approximately70 L, suggesting moderate distribution into tissues 504 plan for children with food allergies. Studies in rats using radiolabeledzafirlukast indicate minimal distribution across the blood-brain barrier 504 plan for children with food allergies.

Metabolism
Zafirlukast is extensively metabolized 504 plan for children with food allergies. The most common metabolic products arehydroxylated metabolites which are excreted in the feces 504 plan for children with food allergies. The metabolites ofzafirlukast identified in plasma are at least 90 times less potent as LTD 4receptor antagonists than zafirlukast in a standard in vitro test of activity 504 plan for children with food allergies. In vitro studies using human liver microsomes showed that the hydroxylated metabolitesof zafirlukast excreted in the feces are formed through the cytochrome P4502C9 (CYP2C9) pathway 504 plan for children with food allergies. Additional in vitro studies utilizing human liver microsomesshow that zafirlukast inhibits the cytochrome P450 CYP3A4 and CYP2C9 isoenzymesat concentrations close to the clinically achieved total plasma concentrations(see Drug Interactions ) 504 plan for children with food allergies.

Excretion
The apparent oral clearance (CL/f) of zafirlukast is approximately 20 L/h 504 plan for children with food allergies. Studiesin the rat and dog suggest that biliary excretion is the primary route of excretion 504 plan for children with food allergies. Following oral administration of radiolabeled zafirlukast to volunteers, urinaryexcretion accounts for approximately 10% of the dose and the remainder is excretedin feces 504 plan for children with food allergies. Zafirlukast is not detected in urine 504 plan for children with food allergies.

In the pivotal bioequivalence study, the mean terminal half-life of zafirlukastis approximately 10 hours in both normal adult subjects and patients with asthma 504 plan for children with food allergies. In other studies, the mean plasma half-life of zafirlukast ranged from approximately8 to 16 hours in both normal subjects and patients with asthma 504 plan for children with food allergies. The pharmacokineticsof zafirlukast are approximately linear over the range from 5 mg to 80 mg 504 plan for children with food allergies. Steady-stateplasma concentrations of zafirlukast are proportional to the dose and predictablefrom single-dose pharmacokinetic data 504 plan for children with food allergies. Accumulation of zafirlukast in the plasmafollowing twice-daily dosing is approximately 45% 504 plan for children with food allergies.

The pharmacokinetic parameters of zafirlukast 20 mg administered as a singledose to 36 male volunteers are shown with the table below 504 plan for children with food allergies.

Mean (% Coefficient of Variation) pharmacokinetic
parameters of zafirlukast following single 20 mg
oral dose administration to male volunteers (n=36) C max
ng/mL t max h AUC
ng·h/mL t 1/2
h CL/f
L/h
326 (31.0) 2 (0.5-5.0) 1137 (34) 13.3 (75.6) 19.4 (32)
1 Median and range

Special Populations
Gender: The pharmacokinetics of zafirlukast are similar in males and females 504 plan for children with food allergies. Weight-adjusted apparent oral clearance does not differ due to gender 504 plan for children with food allergies.

Race: No differences in the pharmacokinetics of zafirlukast due to race havebeen observed 504 plan for children with food allergies.

Elderly: The apparent oral clearance of zafirlukast decreases with age 504 plan for children with food allergies. Inpatients above 65 years of age, there is an approximately 2-3 fold greater Cmax and AUC compared to young adult patients 504 plan for children with food allergies.

Children: Following administration of a single 20 mg dose of zafirlukast to20 boys and girls between 7 and 11 years of age, and in a second study, to 29boys and girls between 5 and 6 years of age, the following pharmacokinetic parameterswere obtained:

Parameter Children age
5-6 years
Mean (% Coefficient
of Variation) Children age
7-11 years
Mean (% Coefficient
of Variation)
C max (ng/mL) 756 (39%) 601 (45%)
AUC (ng·h/mL) 2458 (34%) 2027 (38%)
t max (h) 2.1 (61%) 2.5 (55%)
CL/f (L/h) 9.2 (37%) 11.4 (42%)

Weight unadjusted apparent clearance was 11.4 L/h (42%) in the 7-11 year oldchildren and 9.2 L/h (37%) in the 5-6 year old children, which resulted in greatersystemic drug exposures than that obtained in adults for an identical dose 504 plan for children with food allergies. To maintain similar exposure levels in children compared to adults, a dose of10 mg twice daily is recommended in children 5-11 years of age (see DOSAGE ANDADMINISTRATION ) 504 plan for children with food allergies.

Zafirlukast disposition was unchanged after multiple dosing (20 mg twice daily)in children and the degree of accumulation in plasma was similar to that observedin adults 504 plan for children with food allergies.

Hepatic Insufficiency: In a study of patients with hepatic impairment (biopsy-provencirrhosis), there was a reduced clearance of zafirlukast resulting in a 50-60%greater C max and AUC compared to normal subjects 504 plan for children with food allergies.

Renal Insufficiency: Based on a cross-study comparison, there are no apparentdifferences in the pharmacokinetics of zafirlukast between renally-impairedpatients and normal subjects 504 plan for children with food allergies.

Drug-Drug Interactions
The following drug interaction studies have been conducted with zafirlukast(see PRECAUTIONS , Drug Interactions ) 504 plan for children with food allergies.

Coadministration of multiple doses of zafirlukast (160 mg/day) to steady-statewith a single 25 mg dose of warfarin (a substrate of CYP2C9) resulted in a significantincrease in the mean AUC (+63%) and half-life (+36%) of S-warfarin 504 plan for children with food allergies. The meanprothrombin time increased by approximately 35% 504 plan for children with food allergies. The pharmacokinetics of zafirlukastwere unaffected by coadministration with warfarin 504 plan for children with food allergies.
Coadministration of zafirlukast (80 mg/day) at steady-state with a single doseof a liquid theophylline preparation (6 mg/kg) in 13 asthmatic patients, 18to 44 years of age, resulted in decreased mean plasma concentrations of zafirlukastby approximately 30%, but no effect on plasma theophylline concentrations wasobserved 504 plan for children with food allergies.
Coadministration of zafirlukast (20 mg/day) or placebo at steady-state witha single dose of sustained release theophylline preparation (16 mg/kg) in 16healthy boys and girls (6 through 11 years of age) resulted in no significantdifferences in the pharmacokinetic parameters of theophylline 504 plan for children with food allergies.
Coadministration of zafirlukast dosed at 40 mg twice daily in a single-blind,parallel-group, 3-week study in 39 healthy female subjects taking oral contraceptives,resulted in no significant effect on ethinyl estradiol plasma concentrationsor contraceptive efficacy 504 plan for children with food allergies.
Coadministration of zafirlukast (40 mg/day) with aspirin (650 mg four timesdaily) resulted in mean increased plasma concentrations of zafirlukast by approximately45% 504 plan for children with food allergies.
Coadministration of a single dose of zafirlukast (40 mg) with erythromycin (500mg three times daily for 5 days) to steady-state in 11 asthmatic patients resultedin decreased mean plasma concentrations of zafirlukast by approximately 40%due to a decrease in zafirlukast bioavailability 504 plan for children with food allergies.

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