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risedronate (rih SEH droe nate)

What is the most important information I should know about Actonel?
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach osteoporosis osteomalacia difference. Do not lie down for atleast 30 minutes after taking a dose of Actonel osteoporosis osteomalacia difference.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements osteoporosis osteomalacia difference. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication osteoporosis osteomalacia difference. This timing is very important in getting the maximum amountof medication from each dose osteoporosis osteomalacia difference. Foods, beverages, and other medications greatlydecrease the effect of Actonel osteoporosis osteomalacia difference.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week osteoporosis osteomalacia difference. Follow your doctor's instructions osteoporosis osteomalacia difference.

What is Actonel?
• Actonel alters the cycle of bone formation and breakdown in the body osteoporosis osteomalacia difference.
• Actonel is used to prevent and treat postmenopausal and steroid-causedbone-thinning (osteoporosis) osteoporosis osteomalacia difference. Actonel is also used to treat Paget's diseaseof bone (osteitis deformans) osteoporosis osteomalacia difference.
• Actonel may also be used for purposes other than those listed in thismedication guide osteoporosis osteomalacia difference.

What should I discuss with my healthcare provider before taking Actonel?
• Do not take Actonel without first talking to your doctor if you
· have a problem swallowing, such as a narrowing of the esophagus;
· have esophageal ulcers or esophageal disease;
· have stomach ulcers or other stomach problems;
· have a condition that causes low levels of calcium in the body;
· have a kidney disease; or
· are unable to stand or sit upright for at least 30 minutes osteoporosis osteomalacia difference.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove osteoporosis osteomalacia difference.
• Actonel is in the FDA pregnancy category C osteoporosis osteomalacia difference. This means that it is notknown whether it will be harmful to an unborn baby osteoporosis osteomalacia difference. Do not take Actonel withoutfirst talking to your doctor if you are pregnant or could become pregnant duringtreatment osteoporosis osteomalacia difference.
• It is not known whether Actonel passes into breast milk osteoporosis osteomalacia difference. Do not takeActonel without first talking to your doctor if you are breast-feeding a baby osteoporosis osteomalacia difference.

How should I take Actonel?
• Take Actonel exactly as directed by your doctor osteoporosis osteomalacia difference. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you osteoporosis osteomalacia difference.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements osteoporosis osteomalacia difference. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication osteoporosis osteomalacia difference. This timing is very important in getting the maximum amountof medication from each dose osteoporosis osteomalacia difference. Foods, beverages, and other medications greatlydecrease the effect of Actonel osteoporosis osteomalacia difference.
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach osteoporosis osteomalacia difference. Do not lie down for atleast 30 minutes after taking a dose of Actonel osteoporosis osteomalacia difference.
• Do not crush, chew, or suck the pills osteoporosis osteomalacia difference. Swallow them whole osteoporosis osteomalacia difference.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week osteoporosis osteomalacia difference. Follow your doctor's instructions osteoporosis osteomalacia difference.
• It is important to maintain adequate amounts of calcium and vitamin Din the diet while taking Actonel osteoporosis osteomalacia difference. Discuss with your doctor appropriate amountsof calcium and vitamin D osteoporosis osteomalacia difference.
• Store Actonel at room temperature away from moisture and heat osteoporosis osteomalacia difference.

What happens if I miss a dose?
• If you take Actonel every day and you miss a dose, skip that dose andtake the next regularly scheduled dose the following day osteoporosis osteomalacia difference. Missing one dose willnot make a difference in the treatment osteoporosis osteomalacia difference.
• If you take Actonel once a week and you miss a dose, take the misseddose the next morning osteoporosis osteomalacia difference. Do not take two tablets on the same day osteoporosis osteomalacia difference. Then, returnto your regular schedule, taking one tablet on the chosen morning of the week osteoporosis osteomalacia difference.

What happens if I overdose?
• Seek emergency medical attention osteoporosis osteomalacia difference.
• The symptoms of a Actonel overdose are unknown, but the following symptomsmight be expected: nausea, heartburn, pain in the abdomen, diarrhea, other stomach-relatedsymptoms, muscle cramps, numbness or tingling, uncontrollable facial grimacing,seizures, irritability, and abnormal behavior osteoporosis osteomalacia difference.

What should I avoid while taking Actonel?
• There are no restrictions on food, beverages, or activity while takingActonel, unless otherwise directed by your doctor osteoporosis osteomalacia difference.

What are the possible side effects of Actonel?
• Stop taking Actonel and seek emergency medical attention or contact yourdoctor immediately if you experience any of the following serious side effects:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· difficulty or pain when swallowing;
· pain or burning under the ribs or in the back; or
· new or worsening heartburn osteoporosis osteomalacia difference.
• Other, less serious side effects may be more likely to occur osteoporosis osteomalacia difference. Continueto take Actonel and talk to your doctor if you experience
· abdominal discomfort;
· stomach upset, nausea, vomiting, or diarrhea;
· headache; or
· muscle or joint soreness or aches osteoporosis osteomalacia difference.
• Side effects other than those listed here may also occur osteoporosis osteomalacia difference. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome osteoporosis osteomalacia difference.

What other drugs will affect Actonel?
• Do not take any other medicine, including vitamins, minerals, or othersupplements, at the same time as Actonel unless otherwise directed by your doctor osteoporosis osteomalacia difference. Any drug that is taken at the same time as Actonel can decrease the effectsof this medicine osteoporosis osteomalacia difference.
• Before taking this medication, tell your doctor if you are taking anyof the following medicines:
· an antacid;
· aspirin; or
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin(Indocin, Indocin SR), naproxen (Anaprox, Aleve, Naprosyn), oxaprozin (Daypro),nabumetone (Relafen), piroxicam (Feldene), and others osteoporosis osteomalacia difference.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you are taking any of the medicineslisted above osteoporosis osteomalacia difference.
• Drugs other than those listed here may also interact with Actonel osteoporosis osteomalacia difference. Talkto your doctor and pharmacist before taking any prescription or over-the-countermedicines, including herbal products osteoporosis osteomalacia difference.

Where can I get more information?
• Your pharmacist has more information about Actonel written for healthprofessionals that you may read osteoporosis osteomalacia difference.

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