pathophysiology of osteoporosis

What is the most important information I should know about Actonel?
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach pathophysiology of osteoporosis. Do not lie down for atleast 30 minutes after taking a dose of Actonel pathophysiology of osteoporosis.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements pathophysiology of osteoporosis. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication pathophysiology of osteoporosis. This timing is very important in getting the maximum amountof medication from each dose pathophysiology of osteoporosis. Foods, beverages, and other medications greatlydecrease the effect of Actonel pathophysiology of osteoporosis.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week pathophysiology of osteoporosis. Follow your doctor's instructions pathophysiology of osteoporosis.

What is Actonel?
• Actonel alters the cycle of bone formation and breakdown in the body pathophysiology of osteoporosis.
• Actonel is used to prevent and treat postmenopausal and steroid-causedbone-thinning (osteoporosis) pathophysiology of osteoporosis. Actonel is also used to treat Paget's diseaseof bone (osteitis deformans) pathophysiology of osteoporosis.
• Actonel may also be used for purposes other than those listed in thismedication guide pathophysiology of osteoporosis.

What should I discuss with my healthcare provider before taking Actonel?
• Do not take Actonel without first talking to your doctor if you
· have a problem swallowing, such as a narrowing of the esophagus;
· have esophageal ulcers or esophageal disease;
· have stomach ulcers or other stomach problems;
· have a condition that causes low levels of calcium in the body;
· have a kidney disease; or
· are unable to stand or sit upright for at least 30 minutes pathophysiology of osteoporosis.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove pathophysiology of osteoporosis.
• Actonel is in the FDA pregnancy category C pathophysiology of osteoporosis. This means that it is notknown whether it will be harmful to an unborn baby pathophysiology of osteoporosis. Do not take Actonel withoutfirst talking to your doctor if you are pregnant or could become pregnant duringtreatment pathophysiology of osteoporosis.
• It is not known whether Actonel passes into breast milk pathophysiology of osteoporosis. Do not takeActonel without first talking to your doctor if you are breast-feeding a baby pathophysiology of osteoporosis.

How should I take Actonel?
• Take Actonel exactly as directed by your doctor pathophysiology of osteoporosis. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you pathophysiology of osteoporosis.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements pathophysiology of osteoporosis. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication pathophysiology of osteoporosis. This timing is very important in getting the maximum amountof medication from each dose pathophysiology of osteoporosis. Foods, beverages, and other medications greatlydecrease the effect of Actonel pathophysiology of osteoporosis.
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach pathophysiology of osteoporosis. Do not lie down for atleast 30 minutes after taking a dose of Actonel pathophysiology of osteoporosis.
• Do not crush, chew, or suck the pills pathophysiology of osteoporosis. Swallow them whole pathophysiology of osteoporosis.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week pathophysiology of osteoporosis. Follow your doctor's instructions pathophysiology of osteoporosis.
• It is important to maintain adequate amounts of calcium and vitamin Din the diet while taking Actonel pathophysiology of osteoporosis. Discuss with your doctor appropriate amountsof calcium and vitamin D pathophysiology of osteoporosis.
• Store Actonel at room temperature away from moisture and heat pathophysiology of osteoporosis.

What happens if I miss a dose?
• If you take Actonel every day and you miss a dose, skip that dose andtake the next regularly scheduled dose the following day pathophysiology of osteoporosis. Missing one dose willnot make a difference in the treatment pathophysiology of osteoporosis.
• If you take Actonel once a week and you miss a dose, take the misseddose the next morning pathophysiology of osteoporosis. Do not take two tablets on the same day pathophysiology of osteoporosis. Then, returnto your regular schedule, taking one tablet on the chosen morning of the week pathophysiology of osteoporosis.

What happens if I overdose?
• Seek emergency medical attention pathophysiology of osteoporosis.
• The symptoms of a Actonel overdose are unknown, but the following symptomsmight be expected: nausea, heartburn, pain in the abdomen, diarrhea, other stomach-relatedsymptoms, muscle cramps, numbness or tingling, uncontrollable facial grimacing,seizures, irritability, and abnormal behavior pathophysiology of osteoporosis.

What should I avoid while taking Actonel?
• There are no restrictions on food, beverages, or activity while takingActonel, unless otherwise directed by your doctor pathophysiology of osteoporosis.

What are the possible side effects of Actonel?
• Stop taking Actonel and seek emergency medical attention or contact yourdoctor immediately if you experience any of the following serious side effects:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· difficulty or pain when swallowing;
· pain or burning under the ribs or in the back; or
· new or worsening heartburn pathophysiology of osteoporosis.
• Other, less serious side effects may be more likely to occur pathophysiology of osteoporosis. Continueto take Actonel and talk to your doctor if you experience
· abdominal discomfort;
· stomach upset, nausea, vomiting, or diarrhea;
· headache; or
· muscle or joint soreness or aches pathophysiology of osteoporosis.
• Side effects other than those listed here may also occur pathophysiology of osteoporosis. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome pathophysiology of osteoporosis.

What other drugs will affect Actonel?
• Do not take any other medicine, including vitamins, minerals, or othersupplements, at the same time as Actonel unless otherwise directed by your doctor pathophysiology of osteoporosis. Any drug that is taken at the same time as Actonel can decrease the effectsof this medicine pathophysiology of osteoporosis.
• Before taking this medication, tell your doctor if you are taking anyof the following medicines:
· an antacid;
· aspirin; or
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin(Indocin, Indocin SR), naproxen (Anaprox, Aleve, Naprosyn), oxaprozin (Daypro),nabumetone (Relafen), piroxicam (Feldene), and others pathophysiology of osteoporosis.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you are taking any of the medicineslisted above pathophysiology of osteoporosis.
• Drugs other than those listed here may also interact with Actonel pathophysiology of osteoporosis. Talkto your doctor and pharmacist before taking any prescription or over-the-countermedicines, including herbal products pathophysiology of osteoporosis.

Where can I get more information?
• Your pharmacist has more information about Actonel written for healthprofessionals that you may read pathophysiology of osteoporosis.

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