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risk factors osteoporosis menopaus
risedronate (rih SEH droe nate)

What is the most important information I should know about Actonel?
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach risk factors osteoporosis menopaus. Do not lie down for atleast 30 minutes after taking a dose of Actonel risk factors osteoporosis menopaus.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements risk factors osteoporosis menopaus. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication risk factors osteoporosis menopaus. This timing is very important in getting the maximum amountof medication from each dose risk factors osteoporosis menopaus. Foods, beverages, and other medications greatlydecrease the effect of Actonel risk factors osteoporosis menopaus.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week risk factors osteoporosis menopaus. Follow your doctor's instructions risk factors osteoporosis menopaus.

What is Actonel?
• Actonel alters the cycle of bone formation and breakdown in the body risk factors osteoporosis menopaus.
• Actonel is used to prevent and treat postmenopausal and steroid-causedbone-thinning (osteoporosis) risk factors osteoporosis menopaus. Actonel is also used to treat Paget's diseaseof bone (osteitis deformans) risk factors osteoporosis menopaus.
• Actonel may also be used for purposes other than those listed in thismedication guide risk factors osteoporosis menopaus.

What should I discuss with my healthcare provider before taking Actonel?
• Do not take Actonel without first talking to your doctor if you
· have a problem swallowing, such as a narrowing of the esophagus;
· have esophageal ulcers or esophageal disease;
· have stomach ulcers or other stomach problems;
· have a condition that causes low levels of calcium in the body;
· have a kidney disease; or
· are unable to stand or sit upright for at least 30 minutes risk factors osteoporosis menopaus.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove risk factors osteoporosis menopaus.
• Actonel is in the FDA pregnancy category C risk factors osteoporosis menopaus. This means that it is notknown whether it will be harmful to an unborn baby risk factors osteoporosis menopaus. Do not take Actonel withoutfirst talking to your doctor if you are pregnant or could become pregnant duringtreatment risk factors osteoporosis menopaus.
• It is not known whether Actonel passes into breast milk risk factors osteoporosis menopaus. Do not takeActonel without first talking to your doctor if you are breast-feeding a baby risk factors osteoporosis menopaus.

How should I take Actonel?
• Take Actonel exactly as directed by your doctor risk factors osteoporosis menopaus. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you risk factors osteoporosis menopaus.
• Take Actonel in the morning with a full glass (6 to 8 ounces) of tapwater or bottled water at least 30 minutes before eating any food, drinkingany liquid (other than water), or taking any other medicines including vitamins,minerals, or other supplements risk factors osteoporosis menopaus. Do not take Actonel with mineral water, juice,or any other beverage since these beverages may decrease the effectiveness ofthe medication risk factors osteoporosis menopaus. This timing is very important in getting the maximum amountof medication from each dose risk factors osteoporosis menopaus. Foods, beverages, and other medications greatlydecrease the effect of Actonel risk factors osteoporosis menopaus.
• Although it has been reported less frequently with Actonel, other similardrugs can be very damaging to the mouth and stomach risk factors osteoporosis menopaus. Do not lie down for atleast 30 minutes after taking a dose of Actonel risk factors osteoporosis menopaus.
• Do not crush, chew, or suck the pills risk factors osteoporosis menopaus. Swallow them whole risk factors osteoporosis menopaus.
• The 35 mg Actonel tablets should only be taken once a week, preferablyon the same day each week risk factors osteoporosis menopaus. Follow your doctor's instructions risk factors osteoporosis menopaus.
• It is important to maintain adequate amounts of calcium and vitamin Din the diet while taking Actonel risk factors osteoporosis menopaus. Discuss with your doctor appropriate amountsof calcium and vitamin D risk factors osteoporosis menopaus.
• Store Actonel at room temperature away from moisture and heat risk factors osteoporosis menopaus.

What happens if I miss a dose?
• If you take Actonel every day and you miss a dose, skip that dose andtake the next regularly scheduled dose the following day risk factors osteoporosis menopaus. Missing one dose willnot make a difference in the treatment risk factors osteoporosis menopaus.
• If you take Actonel once a week and you miss a dose, take the misseddose the next morning risk factors osteoporosis menopaus. Do not take two tablets on the same day risk factors osteoporosis menopaus. Then, returnto your regular schedule, taking one tablet on the chosen morning of the week risk factors osteoporosis menopaus.

What happens if I overdose?
• Seek emergency medical attention risk factors osteoporosis menopaus.
• The symptoms of a Actonel overdose are unknown, but the following symptomsmight be expected: nausea, heartburn, pain in the abdomen, diarrhea, other stomach-relatedsymptoms, muscle cramps, numbness or tingling, uncontrollable facial grimacing,seizures, irritability, and abnormal behavior risk factors osteoporosis menopaus.

What should I avoid while taking Actonel?
• There are no restrictions on food, beverages, or activity while takingActonel, unless otherwise directed by your doctor risk factors osteoporosis menopaus.

What are the possible side effects of Actonel?
• Stop taking Actonel and seek emergency medical attention or contact yourdoctor immediately if you experience any of the following serious side effects:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· difficulty or pain when swallowing;
· pain or burning under the ribs or in the back; or
· new or worsening heartburn risk factors osteoporosis menopaus.
• Other, less serious side effects may be more likely to occur risk factors osteoporosis menopaus. Continueto take Actonel and talk to your doctor if you experience
· abdominal discomfort;
· stomach upset, nausea, vomiting, or diarrhea;
· headache; or
· muscle or joint soreness or aches risk factors osteoporosis menopaus.
• Side effects other than those listed here may also occur risk factors osteoporosis menopaus. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome risk factors osteoporosis menopaus.

What other drugs will affect Actonel?
• Do not take any other medicine, including vitamins, minerals, or othersupplements, at the same time as Actonel unless otherwise directed by your doctor risk factors osteoporosis menopaus. Any drug that is taken at the same time as Actonel can decrease the effectsof this medicine risk factors osteoporosis menopaus.
• Before taking this medication, tell your doctor if you are taking anyof the following medicines:
· an antacid;
· aspirin; or
· a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin,Advil, Nuprin, others), ketoprofen (Orudis KT, Orudis, Oruvail), indomethacin(Indocin, Indocin SR), naproxen (Anaprox, Aleve, Naprosyn), oxaprozin (Daypro),nabumetone (Relafen), piroxicam (Feldene), and others risk factors osteoporosis menopaus.
• You may not be able to take Actonel, or you may require a dosage adjustmentor special monitoring during treatment if you are taking any of the medicineslisted above risk factors osteoporosis menopaus.
• Drugs other than those listed here may also interact with Actonel risk factors osteoporosis menopaus. Talkto your doctor and pharmacist before taking any prescription or over-the-countermedicines, including herbal products risk factors osteoporosis menopaus.

Where can I get more information?
• Your pharmacist has more information about Actonel written for healthprofessionals that you may read risk factors osteoporosis menopaus.

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