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acto administrativo
Pioglitazone (pie oh GLIH ta zone)

What is the most important information I should know about Actos?
• Usually, liver function is monitored with blood tests at the start oftreatment, every two months for the first year of treatment, and periodicallythereafter during treatment with Actos acto administrativo. Notify your doctor immediately if youdevelop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite,yellow skin or eyes, or dark urine acto administrativo. These symptoms may be early signs of liverproblems acto administrativo.
• Notify your doctor immediately if you experience an unusually rapid increasein weight or edema (water retention), shortness of breath, or chest pain duringtreatment with Actos acto administrativo. These may be early symptoms of heart problems acto administrativo.
• Actos usually does not cause hypoglycemia (low blood sugar) acto administrativo. However,hypoglycemia may occur as a result of skipped meals, excessive exercise, oralcohol consumption while taking Actos acto administrativo. Know the signs and symptoms of hypoglycemia,which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating,tremor, and nausea acto administrativo. Carry hard candy or glucose tablets with you to treat episodesof low blood sugar acto administrativo.
• Actos may decrease the effects of some birth control pills acto administrativo. Additionalmeasures may be necessary to prevent pregnancy while taking Actos acto administrativo. Talk to yourdoctor about the use of birth control acto administrativo.


What is Actos?
• Actos is an antihyperglycemic agent acto administrativo. It helps the body respond betterto insulin and it reduces the amount of sugar produced by the liver acto administrativo. It canhelp control blood sugar levels acto administrativo.
• Actos is used, along with diet and exercise, in the treatment of non-insulin-dependentdiabetes mellitus (type II diabetes) acto administrativo. Actos may also be used with a sulfonylurea(e.g., Diabeta, Glucotrol, Micronase, others), metformin (Glucophage), or insulinwhen diet and exercise plus any one of these medicines alone do not result inadequate blood sugar control acto administrativo.
• Actos may also be used for purposes other than those listed in this medicationguide acto administrativo.


What should I discuss with my healthcare provider before taking Actos?
• Do not take Actos without first talking to your doctor if you have liverdisease acto administrativo.
• Before taking this medication, tell your doctor if you
· have heart failure or heart disease;
· have edema (water retention or swelling);
· have type 1 diabetes mellitus (insulin-dependent diabetes);
· have a serious infection, illness, or injury; or
· need surgery acto administrativo.
• You may not be able to take Actos, or you may need a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove acto administrativo.
• Treatment with Actos may cause resumption of fertility by allowing forthe return of ovulation (production of eggs) in certain women with insulin resistancewho were not ovulating before treatment with Actos acto administrativo. Therefore, pregnancy mayoccur and birth control may be a consideration acto administrativo.
• Actos is in the FDA pregnancy category C acto administrativo. This means that it is not knownwhether Actos will be harmful to an unborn baby acto administrativo. Generally, insulin is the drugof choice for controlling diabetes during pregnancy acto administrativo. Do not take Actos withoutfirst talking to your doctor if you are pregnant or could become pregnant duringtreatment acto administrativo.
• It is not known whether Actos passes into breast milk acto administrativo. Do not take Actoswithout first talking to your doctor if you are breast-feeding a baby acto administrativo.
• The safety and effectiveness of Actos have not been established for children acto administrativo.


How should I take Actos?
• Take Actos exactly as directed by your doctor acto administrativo. If you do not understandthese instructions, ask your pharmacist, nurse, or doctor to explain them toyou acto administrativo.
• Take each dose with a full glass of water acto administrativo.
• Actos can be taken with or without food or meals acto administrativo.
• Usually, liver function is monitored with blood tests at the start oftreatment, every two months for the first year of treatment, and periodicallythereafter during treatment with Actos acto administrativo. Notify your doctor immediately if youdevelop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite,yellow skin or eyes, or dark urine acto administrativo. These symptoms may be early signs of liverproblems acto administrativo.
• Although Actos does not usually cause hypoglycemia (low blood sugar),hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption acto administrativo. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness,weakness, dizziness, fast heartbeat, sweating, tremor, and nausea acto administrativo. Carry a pieceof hard candy or glucose tablets with you to treat episodes of low blood sugar acto administrativo.
• Store Actos at room temperature away from moisture and heat acto administrativo.


What happens if I miss a dose?
• Take the missed dose as soon as you remember acto administrativo. If you do not rememberuntil the next day, skip the missed dose and take only the next regularly scheduleddose acto administrativo. Do not take a double dose acto administrativo.


What happens if I overdose?
• Seek emergency medical attention acto administrativo.
• Symptoms of a Actos overdose are not known acto administrativo.


What should I avoid while taking Actos?
• Follow any diet, medication, and exercise routines closely acto administrativo. Changingany of these factors can affect blood sugar levels acto administrativo.
• Avoid alcohol acto administrativo. It lowers blood sugar and may interfere with diabetestreatment acto administrativo.
• Tell your doctor and dentist that you are taking this medication beforehaving surgery acto administrativo.
• Do not take over-the-counter or prescription cough, cold, allergy, pain,or weight-loss medications during treatment with Actos without first talkingto your doctor acto administrativo.


What are the possible side effects of Actos?
• If you experience any of the following serious side effects, stop takingActos and seek emergency medical attention or notify your doctor immediately:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· nausea, vomiting, abdominal pain, or loss of appetite;
· unusual fatigue;
· yellowing of the skin or eyes; or
· dark urine acto administrativo.
• Notify your doctor immediately if you experience an unusually rapid increasein weight or edema (swelling, water retention), shortness of breath, or chestpain during treatment with Actos acto administrativo. These may be early symptoms of heart problems acto administrativo.
• Although Actos does not usually cause hypoglycemia (low blood sugar),hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption acto administrativo. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness,weakness, dizziness, fast heartbeat, sweating, tremor, and nausea acto administrativo. Carry a pieceof hard candy or glucose tablets with you to treat episodes of low blood sugar acto administrativo.
• Other less serious side effects may also occur acto administrativo. Continue to take Actosand talk to your doctor if you experience:
· headache;
· muscle aches; or
· sore throat, nasal discharge, or cold symptoms acto administrativo.
• Side effects other than those listed here may also occur acto administrativo. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome acto administrativo.


What other drugs will affect Actos?
• Actos may decrease the effects of some birth control pills acto administrativo. Additionalmeasures may be necessary to prevent pregnancy while taking Actos acto administrativo. Talk to yourdoctor about the use of birth control acto administrativo.
• Before taking Actos, tell your doctor if you are taking ketoconazole(Nizoral) acto administrativo. Ketoconazole may interact with Actos acto administrativo.
• Do not take over-the-counter or prescription cough, cold, allergy, pain,or weight-loss medications during treatment with Actos without first talkingto your doctor acto administrativo.
• Drugs other than those listed here may also interact with Actos or affectyour condition acto administrativo. Talk to your doctor and pharmacist before taking any prescriptionor over-the-counter medicines, including herbal products acto administrativo.


Where can I get more information?
• Your pharmacist has additional information about Actos written for healthprofessionals that you may read acto administrativo.


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