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actos or piaglitazone and multiple sclerosis
Pioglitazone (pie oh GLIH ta zone)

What is the most important information I should know about Actos?
• Usually, liver function is monitored with blood tests at the start oftreatment, every two months for the first year of treatment, and periodicallythereafter during treatment with Actos actos or piaglitazone and multiple sclerosis. Notify your doctor immediately if youdevelop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite,yellow skin or eyes, or dark urine actos or piaglitazone and multiple sclerosis. These symptoms may be early signs of liverproblems actos or piaglitazone and multiple sclerosis.
• Notify your doctor immediately if you experience an unusually rapid increasein weight or edema (water retention), shortness of breath, or chest pain duringtreatment with Actos actos or piaglitazone and multiple sclerosis. These may be early symptoms of heart problems actos or piaglitazone and multiple sclerosis.
• Actos usually does not cause hypoglycemia (low blood sugar) actos or piaglitazone and multiple sclerosis. However,hypoglycemia may occur as a result of skipped meals, excessive exercise, oralcohol consumption while taking Actos actos or piaglitazone and multiple sclerosis. Know the signs and symptoms of hypoglycemia,which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating,tremor, and nausea actos or piaglitazone and multiple sclerosis. Carry hard candy or glucose tablets with you to treat episodesof low blood sugar actos or piaglitazone and multiple sclerosis.
• Actos may decrease the effects of some birth control pills actos or piaglitazone and multiple sclerosis. Additionalmeasures may be necessary to prevent pregnancy while taking Actos actos or piaglitazone and multiple sclerosis. Talk to yourdoctor about the use of birth control actos or piaglitazone and multiple sclerosis.

What is Actos?
• Actos is an antihyperglycemic agent actos or piaglitazone and multiple sclerosis. It helps the body respond betterto insulin and it reduces the amount of sugar produced by the liver actos or piaglitazone and multiple sclerosis. It canhelp control blood sugar levels actos or piaglitazone and multiple sclerosis.
• Actos is used, along with diet and exercise, in the treatment of non-insulin-dependentdiabetes mellitus (type II diabetes) actos or piaglitazone and multiple sclerosis. Actos may also be used with a sulfonylurea(e.g., Diabeta, Glucotrol, Micronase, others), metformin (Glucophage), or insulinwhen diet and exercise plus any one of these medicines alone do not result inadequate blood sugar control actos or piaglitazone and multiple sclerosis.
• Actos may also be used for purposes other than those listed in this medicationguide actos or piaglitazone and multiple sclerosis.

What should I discuss with my healthcare provider before taking Actos?
• Do not take Actos without first talking to your doctor if you have liverdisease actos or piaglitazone and multiple sclerosis.
• Before taking this medication, tell your doctor if you
· have heart failure or heart disease;
· have edema (water retention or swelling);
· have type 1 diabetes mellitus (insulin-dependent diabetes);
· have a serious infection, illness, or injury; or
· need surgery actos or piaglitazone and multiple sclerosis.
• You may not be able to take Actos, or you may need a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove actos or piaglitazone and multiple sclerosis.
• Treatment with Actos may cause resumption of fertility by allowing forthe return of ovulation (production of eggs) in certain women with insulin resistancewho were not ovulating before treatment with Actos actos or piaglitazone and multiple sclerosis. Therefore, pregnancy mayoccur and birth control may be a consideration actos or piaglitazone and multiple sclerosis.
• Actos is in the FDA pregnancy category C actos or piaglitazone and multiple sclerosis. This means that it is not knownwhether Actos will be harmful to an unborn baby actos or piaglitazone and multiple sclerosis. Generally, insulin is the drugof choice for controlling diabetes during pregnancy actos or piaglitazone and multiple sclerosis. Do not take Actos withoutfirst talking to your doctor if you are pregnant or could become pregnant duringtreatment actos or piaglitazone and multiple sclerosis.
• It is not known whether Actos passes into breast milk actos or piaglitazone and multiple sclerosis. Do not take Actoswithout first talking to your doctor if you are breast-feeding a baby actos or piaglitazone and multiple sclerosis.
• The safety and effectiveness of Actos have not been established for children actos or piaglitazone and multiple sclerosis.

How should I take Actos?
• Take Actos exactly as directed by your doctor actos or piaglitazone and multiple sclerosis. If you do not understandthese instructions, ask your pharmacist, nurse, or doctor to explain them toyou actos or piaglitazone and multiple sclerosis.
• Take each dose with a full glass of water actos or piaglitazone and multiple sclerosis.
• Actos can be taken with or without food or meals actos or piaglitazone and multiple sclerosis.
• Usually, liver function is monitored with blood tests at the start oftreatment, every two months for the first year of treatment, and periodicallythereafter during treatment with Actos actos or piaglitazone and multiple sclerosis. Notify your doctor immediately if youdevelop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite,yellow skin or eyes, or dark urine actos or piaglitazone and multiple sclerosis. These symptoms may be early signs of liverproblems actos or piaglitazone and multiple sclerosis.
• Although Actos does not usually cause hypoglycemia (low blood sugar),hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption actos or piaglitazone and multiple sclerosis. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness,weakness, dizziness, fast heartbeat, sweating, tremor, and nausea actos or piaglitazone and multiple sclerosis. Carry a pieceof hard candy or glucose tablets with you to treat episodes of low blood sugar actos or piaglitazone and multiple sclerosis.
• Store Actos at room temperature away from moisture and heat actos or piaglitazone and multiple sclerosis.

What happens if I miss a dose?
• Take the missed dose as soon as you remember actos or piaglitazone and multiple sclerosis. If you do not rememberuntil the next day, skip the missed dose and take only the next regularly scheduleddose actos or piaglitazone and multiple sclerosis. Do not take a double dose actos or piaglitazone and multiple sclerosis.

What happens if I overdose?
• Seek emergency medical attention actos or piaglitazone and multiple sclerosis.
• Symptoms of a Actos overdose are not known actos or piaglitazone and multiple sclerosis.

What should I avoid while taking Actos?
• Follow any diet, medication, and exercise routines closely actos or piaglitazone and multiple sclerosis. Changingany of these factors can affect blood sugar levels actos or piaglitazone and multiple sclerosis.
• Avoid alcohol actos or piaglitazone and multiple sclerosis. It lowers blood sugar and may interfere with diabetestreatment actos or piaglitazone and multiple sclerosis.
• Tell your doctor and dentist that you are taking this medication beforehaving surgery actos or piaglitazone and multiple sclerosis.
• Do not take over-the-counter or prescription cough, cold, allergy, pain,or weight-loss medications during treatment with Actos without first talkingto your doctor actos or piaglitazone and multiple sclerosis.

What are the possible side effects of Actos?
• If you experience any of the following serious side effects, stop takingActos and seek emergency medical attention or notify your doctor immediately:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· nausea, vomiting, abdominal pain, or loss of appetite;
· unusual fatigue;
· yellowing of the skin or eyes; or
· dark urine actos or piaglitazone and multiple sclerosis.
• Notify your doctor immediately if you experience an unusually rapid increasein weight or edema (swelling, water retention), shortness of breath, or chestpain during treatment with Actos actos or piaglitazone and multiple sclerosis. These may be early symptoms of heart problems actos or piaglitazone and multiple sclerosis.
• Although Actos does not usually cause hypoglycemia (low blood sugar),hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption actos or piaglitazone and multiple sclerosis. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness,weakness, dizziness, fast heartbeat, sweating, tremor, and nausea actos or piaglitazone and multiple sclerosis. Carry a pieceof hard candy or glucose tablets with you to treat episodes of low blood sugar actos or piaglitazone and multiple sclerosis.
• Other less serious side effects may also occur actos or piaglitazone and multiple sclerosis. Continue to take Actosand talk to your doctor if you experience:
· headache;
· muscle aches; or
· sore throat, nasal discharge, or cold symptoms actos or piaglitazone and multiple sclerosis.
• Side effects other than those listed here may also occur actos or piaglitazone and multiple sclerosis. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome actos or piaglitazone and multiple sclerosis.

What other drugs will affect Actos?
• Actos may decrease the effects of some birth control pills actos or piaglitazone and multiple sclerosis. Additionalmeasures may be necessary to prevent pregnancy while taking Actos actos or piaglitazone and multiple sclerosis. Talk to yourdoctor about the use of birth control actos or piaglitazone and multiple sclerosis.
• Before taking Actos, tell your doctor if you are taking ketoconazole(Nizoral) actos or piaglitazone and multiple sclerosis. Ketoconazole may interact with Actos actos or piaglitazone and multiple sclerosis.
• Do not take over-the-counter or prescription cough, cold, allergy, pain,or weight-loss medications during treatment with Actos without first talkingto your doctor actos or piaglitazone and multiple sclerosis.
• Drugs other than those listed here may also interact with Actos or affectyour condition actos or piaglitazone and multiple sclerosis. Talk to your doctor and pharmacist before taking any prescriptionor over-the-counter medicines, including herbal products actos or piaglitazone and multiple sclerosis.

Where can I get more information?
• Your pharmacist has additional information about Actos written for healthprofessionals that you may read actos or piaglitazone and multiple sclerosis.

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