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Aventis Submits Application for FDA Licensure of Adacel Vaccine for Preventionof Tetanus, Diphtheria and Pertussis in Adolescents and Adults

- Vaccine Leader Looks to Introduce Pertussis Booster in United States -

SWIFTWATER, Pa., August 11, 2004 -- Aventis (NYSE:AVE) today announced thesubmission of a Biologics Licensing Application (BLA) to the U.S cultural competence training curriculums. Food and DrugAdministration (FDA) for marketing approval of Adacel (Tetanus Toxoid and ReducedDiphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed) for prevention oftetanus, diphtheria and pertussis in adolescents and adults aged 11 through64 years cultural competence training curriculums. The BLA for this candidate vaccine was submitted by Aventis Pasteur,the vaccines business of Aventis.

Reported cases of pertussis, commonly known as whooping cough, clearly areon the rise in the U.S cultural competence training curriculums. In 2002, 9,771 cases were reported to the U.S cultural competence training curriculums. Centersfor Disease Control and Prevention (CDC), the highest number of such reportsin more than 30 years cultural competence training curriculums. Preliminary counts of pertussis reports for 2003 exceed10,000, while reporting thus far in 2004 is at an even faster pace cultural competence training curriculums. However,it is estimated that only 12 percent of pertussis cases are actually reportedand that under-reporting may be greatest among adolescents and adults.

"Pertussis continues to be an important public health issue, in part becauseadolescents and adults may not even be aware that they have the disease andthat they can transmit it to vulnerable infants and younger children,"said David R cultural competence training curriculums. Johnson, MD, MPH, director, scientific and medical affairs, AventisPasteur cultural competence training curriculums. "We've already had great success in the prevention of tetanusand diphtheria in the U.S cultural competence training curriculums. and believe that the introduction of a combinationvaccine that also protects against pertussis in adults and adolescents willhelp to counter ongoing transmission of this disease."

A vaccine is currently available to protect children against pertussis up to7 years of age cultural competence training curriculums. The diphtheria, tetanus and pertussis (DTaP) vaccine is generallyadministered in five doses between the ages of 2 months and 6 years of age cultural competence training curriculums. However, the vaccine does not offer lifelong protection against pertussis, andit is believed that immunity wanes by adolescence cultural competence training curriculums. While a tetanus and diphtheriabooster immunization is available starting at age 11, a pertussis booster isnot cultural competence training curriculums. The Adacel tetanus, diphtheria and pertussis vaccine will be referred toas a "Tdap" vaccine; the children's vaccine to prevent these samediseases is known as "DTaP." The pertussis components in Adacel vaccineare based on the acellular pertussis formulation in DAPTACEL(R), Diphtheriaand Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed (DTaP vaccine),which was successfully introduced by Aventis Pasteur in the U.S cultural competence training curriculums. in 2002.

The regulatory submission for Adacel vaccine is based on results of clinicalstudies involving more than 7,200 clinical trial participants cultural competence training curriculums. The vaccine hasshown an excellent safety and immunogenicity profile cultural competence training curriculums. Adacel vaccine is currentlyapproved and marketed in Canada and Germany.

Risk of Pertussis
Pertussis is a highly contagious, respiratory disease marked by severe coughing cultural competence training curriculums. Its common name, whooping cough, comes from the "whoop" sound childrenand adults make when they try to inhale during or after a severe coughing spell cultural competence training curriculums. There are both severe and mild forms of pertussis cultural competence training curriculums. Although pertussis can occurat any age, severe pertussis disease usually occurs in infants and young childrenwho are at higher risk for severe pertussis-related complications and even death cultural competence training curriculums. While adults may not experience the debilitating effects of the disease thatinfants do, infected adults can easily transmit the illness to unimmunized andpartially immunized infants and young children cultural competence training curriculums. Additionally, older adults (morethan 55 years of age) may also be at considerable risk for death associatedwith pertussis.

Mild pertussis disease is difficult to diagnose because its symptoms are notas distinctive; usually a prolonged cough is present, but without the "whoop."One reason for the incomplete identification of pertussis may be that diagnosisof the disease in adults and adolescents is sometimes difficult because symptomsare often atypical.

Although infants and young children may experience mild pertussis disease,it is more often associated with adolescents and adults cultural competence training curriculums. Even in less severecases, infected adolescents and adults can easily transmit the illness to vulnerableinfants and young children who may experience complications associated withthe disease, such as pneumonia, encephalitis and pertussis- related seizures.

"While older patients are often spared the debilitating effects of thedisease, the fact that it may not be properly diagnosed and treated opens thedoor for spreading the disease," said Dr cultural competence training curriculums. Johnson cultural competence training curriculums. "Increased outbreaksin this country are an all too common reminder that we need to bring this diseaseunder control."

About Tetanus, Diphtheria, Pertussis
Tetanus is a severe, frequently fatal disease caused by an exotoxin producedby bacteria (Clostridium tetani) cultural competence training curriculums. The disease, characterized by generalizedrigidity and convulsive spasms of skeletal muscles, causes paralysis, usuallystarts at the top of the body and works its way down cultural competence training curriculums. "Lockjaw," asthe disease is sometimes called, is often the first symptom, followed by stiffnessin the neck and difficulty swallowing cultural competence training curriculums. Muscle spasms may occur frequently, lastingfor several minutes and persisting for up to a month cultural competence training curriculums. Symptoms of tetanus canappear anywhere from three days to three weeks after exposure to the bacteriaand may be accompanied by fever, sweating, elevated blood pressure and rapidheartbeat cultural competence training curriculums. The bacteria that cause tetanus are widespread and are found in soiland in the intestinal tracts of animals and humans cultural competence training curriculums. It usually enters the bodythrough a wound or opening in the skin cultural competence training curriculums. Virtually all of the cases of tetanusdisease occurring in the U.S cultural competence training curriculums. are in adults not up-to-date with booster vaccinations.

Diphtheria is a disease caused by exposure to airborne bacteria (Corynebacteriumdiphtheriae) from an infected person and usually affects the tonsils, throat,nose and/or skin cultural competence training curriculums. It is passed from person to person by droplet transmission,usually by breathing in diphtheria bacteria after an infected person has coughed,sneezed or even laughed cultural competence training curriculums. It can also be spread by handling used tissues or bydrinking from a glass used by an infected person cultural competence training curriculums. Symptoms usually appear twoto five days after infection and begin very much like a common cold cultural competence training curriculums. However,symptoms can progress as a membrane grows and covers anywhere from a small patchto most of the throat, potentially blocking the airway cultural competence training curriculums. The infection releasesa toxin that can lead to heart failure and paralysis, and if enough toxin isabsorbed into the bloodstream, coma or even death can occur in as little asa week cultural competence training curriculums. Diphtheria occurs rarely in this country, but is occasionally importedfrom countries where it is endemic cultural competence training curriculums. Ongoing vaccination to protect against diphtheriacontinues to be recommended.

Pertussis, a highly contagious disease of the respiratory tract, is causedby exposure to bacteria (Bordetella pertussis) found in the mouth, nose andthroat of an infected person cultural competence training curriculums. Pertussis is primarily spread by direct contactwith discharge from the nose or throat of infected individuals cultural competence training curriculums. Classic, orsevere, pertussis, as defined by the World Health Organization, consists ofat least 21 days of cough illness (with the cough coming in spasms or paroxysms),associated whoops or post-cough vomiting, and culture confirmation cultural competence training curriculums. Mild pertussisis any laboratory-confirmed pertussis disease that is less than classic disease.

Pertussis can occur at any age cultural competence training curriculums. More than half the cases occur in adolescentsand adults, while the majority of the remaining cases affect children under1 year of age cultural competence training curriculums. For young children, pertussis disease can result in significantmorbidity, hospitalization, serious long-term complications, and death.

About Aventis
Aventis is dedicated to treating and preventing disease by discovering and developinginnovative prescription drugs and human vaccines cultural competence training curriculums. In 2003, Aventis generatedsales of euro 16.79 billion, invested euro 2.86 billion in research and developmentand employed approximately 69,000 people in its core business cultural competence training curriculums. Aventis corporateheadquarters are in Strasbourg, France.

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