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SWIFTWATER, Pa., August 11, 2004 -- Aventis (NYSE:AVE) today announced thesubmission of a Biologics Licensing Application (BLA) to the U.S definition of curriculum. Food and DrugAdministration (FDA) for marketing approval of Adacel (Tetanus Toxoid and ReducedDiphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed) for prevention oftetanus, diphtheria and pertussis in adolescents and adults aged 11 through64 years definition of curriculum. The BLA for this candidate vaccine was submitted by Aventis Pasteur,the vaccines business of Aventis.

Reported cases of pertussis, commonly known as whooping cough, clearly areon the rise in the U.S definition of curriculum. In 2002, 9,771 cases were reported to the U.S definition of curriculum. Centersfor Disease Control and Prevention (CDC), the highest number of such reportsin more than 30 years definition of curriculum. Preliminary counts of pertussis reports for 2003 exceed10,000, while reporting thus far in 2004 is at an even faster pace definition of curriculum. However,it is estimated that only 12 percent of pertussis cases are actually reportedand that under-reporting may be greatest among adolescents and adults.

"Pertussis continues to be an important public health issue, in part becauseadolescents and adults may not even be aware that they have the disease andthat they can transmit it to vulnerable infants and younger children,"said David R definition of curriculum. Johnson, MD, MPH, director, scientific and medical affairs, AventisPasteur definition of curriculum. "We've already had great success in the prevention of tetanusand diphtheria in the U.S definition of curriculum. and believe that the introduction of a combinationvaccine that also protects against pertussis in adults and adolescents willhelp to counter ongoing transmission of this disease."

A vaccine is currently available to protect children against pertussis up to7 years of age definition of curriculum. The diphtheria, tetanus and pertussis (DTaP) vaccine is generallyadministered in five doses between the ages of 2 months and 6 years of age definition of curriculum. However, the vaccine does not offer lifelong protection against pertussis, andit is believed that immunity wanes by adolescence definition of curriculum. While a tetanus and diphtheriabooster immunization is available starting at age 11, a pertussis booster isnot definition of curriculum. The Adacel tetanus, diphtheria and pertussis vaccine will be referred toas a "Tdap" vaccine; the children's vaccine to prevent these samediseases is known as "DTaP." The pertussis components in Adacel vaccineare based on the acellular pertussis formulation in DAPTACEL(R), Diphtheriaand Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed (DTaP vaccine),which was successfully introduced by Aventis Pasteur in the U.S definition of curriculum. in 2002.

The regulatory submission for Adacel vaccine is based on results of clinicalstudies involving more than 7,200 clinical trial participants definition of curriculum. The vaccine hasshown an excellent safety and immunogenicity profile definition of curriculum. Adacel vaccine is currentlyapproved and marketed in Canada and Germany.

Risk of Pertussis
Pertussis is a highly contagious, respiratory disease marked by severe coughing definition of curriculum. Its common name, whooping cough, comes from the "whoop" sound childrenand adults make when they try to inhale during or after a severe coughing spell definition of curriculum. There are both severe and mild forms of pertussis definition of curriculum. Although pertussis can occurat any age, severe pertussis disease usually occurs in infants and young childrenwho are at higher risk for severe pertussis-related complications and even death definition of curriculum. While adults may not experience the debilitating effects of the disease thatinfants do, infected adults can easily transmit the illness to unimmunized andpartially immunized infants and young children definition of curriculum. Additionally, older adults (morethan 55 years of age) may also be at considerable risk for death associatedwith pertussis.

Mild pertussis disease is difficult to diagnose because its symptoms are notas distinctive; usually a prolonged cough is present, but without the "whoop."One reason for the incomplete identification of pertussis may be that diagnosisof the disease in adults and adolescents is sometimes difficult because symptomsare often atypical.

Although infants and young children may experience mild pertussis disease,it is more often associated with adolescents and adults definition of curriculum. Even in less severecases, infected adolescents and adults can easily transmit the illness to vulnerableinfants and young children who may experience complications associated withthe disease, such as pneumonia, encephalitis and pertussis- related seizures.

"While older patients are often spared the debilitating effects of thedisease, the fact that it may not be properly diagnosed and treated opens thedoor for spreading the disease," said Dr definition of curriculum. Johnson definition of curriculum. "Increased outbreaksin this country are an all too common reminder that we need to bring this diseaseunder control."

About Tetanus, Diphtheria, Pertussis
Tetanus is a severe, frequently fatal disease caused by an exotoxin producedby bacteria (Clostridium tetani) definition of curriculum. The disease, characterized by generalizedrigidity and convulsive spasms of skeletal muscles, causes paralysis, usuallystarts at the top of the body and works its way down definition of curriculum. "Lockjaw," asthe disease is sometimes called, is often the first symptom, followed by stiffnessin the neck and difficulty swallowing definition of curriculum. Muscle spasms may occur frequently, lastingfor several minutes and persisting for up to a month definition of curriculum. Symptoms of tetanus canappear anywhere from three days to three weeks after exposure to the bacteriaand may be accompanied by fever, sweating, elevated blood pressure and rapidheartbeat definition of curriculum. The bacteria that cause tetanus are widespread and are found in soiland in the intestinal tracts of animals and humans definition of curriculum. It usually enters the bodythrough a wound or opening in the skin definition of curriculum. Virtually all of the cases of tetanusdisease occurring in the U.S definition of curriculum. are in adults not up-to-date with booster vaccinations.

Diphtheria is a disease caused by exposure to airborne bacteria (Corynebacteriumdiphtheriae) from an infected person and usually affects the tonsils, throat,nose and/or skin definition of curriculum. It is passed from person to person by droplet transmission,usually by breathing in diphtheria bacteria after an infected person has coughed,sneezed or even laughed definition of curriculum. It can also be spread by handling used tissues or bydrinking from a glass used by an infected person definition of curriculum. Symptoms usually appear twoto five days after infection and begin very much like a common cold definition of curriculum. However,symptoms can progress as a membrane grows and covers anywhere from a small patchto most of the throat, potentially blocking the airway definition of curriculum. The infection releasesa toxin that can lead to heart failure and paralysis, and if enough toxin isabsorbed into the bloodstream, coma or even death can occur in as little asa week definition of curriculum. Diphtheria occurs rarely in this country, but is occasionally importedfrom countries where it is endemic definition of curriculum. Ongoing vaccination to protect against diphtheriacontinues to be recommended.

Pertussis, a highly contagious disease of the respiratory tract, is causedby exposure to bacteria (Bordetella pertussis) found in the mouth, nose andthroat of an infected person definition of curriculum. Pertussis is primarily spread by direct contactwith discharge from the nose or throat of infected individuals definition of curriculum. Classic, orsevere, pertussis, as defined by the World Health Organization, consists ofat least 21 days of cough illness (with the cough coming in spasms or paroxysms),associated whoops or post-cough vomiting, and culture confirmation definition of curriculum. Mild pertussisis any laboratory-confirmed pertussis disease that is less than classic disease.

Pertussis can occur at any age definition of curriculum. More than half the cases occur in adolescentsand adults, while the majority of the remaining cases affect children under1 year of age definition of curriculum. For young children, pertussis disease can result in significantmorbidity, hospitalization, serious long-term complications, and death.

About Aventis
Aventis is dedicated to treating and preventing disease by discovering and developinginnovative prescription drugs and human vaccines definition of curriculum. In 2003, Aventis generatedsales of euro 16.79 billion, invested euro 2.86 billion in research and developmentand employed approximately 69,000 people in its core business definition of curriculum. Aventis corporateheadquarters are in Strasbourg, France.

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