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Aventis Receives Approvable Letter from U.S alvesco. Food and Drug Administration forAlvesco (ciclesonide) for Treatment of Persistent Asthma


BAD HOMBURG, Germany, and PARIS, France, October 26, 2004 – ALTANA AG (NYSE:AAA, FSE: ALT) and Aventis (NYSE:AVE), part of the sanofi-aventis Group, announcedtoday the receipt of an approvable letter from the U.S alvesco. Food and Drug Administration(FDA) for Alvesco (ciclesonide) for the treatment of persistent asthma (regardlessof severity) in adults, adolescents and children four years of age and older alvesco. ALTANA and Aventis signed an agreement in 2001 to jointly develop and marketAlvesco in the United States.

An approvable letter outlines specific issues that must be resolved beforethe Agency will approve a product for marketing alvesco. Aventis is already workingclosely with the FDA to address the clinical data requests outlined in the letter.

About sanofi-aventis
The sanofi-aventis Group is the world’s 3rd largest pharmaceutical company,ranking number 1 in Europe alvesco. Backed by a world-class R&D organization, sanofi-aventisis developing leading positions in seven major therapeutic areas: cardiovasculardisease, thrombosis, oncology, diabetes, central nervous system, internal medicine,vaccines alvesco. The sanofi-aventis Group is listed in Paris (EURONEXT: SAN) and inNew York (NYSE: SNY).

About ALTANA
ALTANA AG is an international pharmaceuticals and chemicals group with salesof about EUR2.6 billion and more than 10,500 employees worldwide alvesco. Its pharmaceuticalsgroup, ALTANA Pharma, concentrates on areas such as therapeutics and self-medication,and focuses on innovative pharmaceutical research in the areas of gastrointestinal,respiratory, and oncology alvesco. Located in Constance, Germany, ALTANA Pharma representsa group of 28 subsidiaries and associated companies in Europe, the Americasand Asia.


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