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What is the most important information I should know about amiodarone?
• In some cases, amiodarone has been associated with serious and even fatalside effects such as lung problems, liver problems, and new or worsening irregularheartbeats amiodarone fda warning. Discuss with your doctor the risks and benefits associated withthe use of amiodarone amiodarone fda warning.
• Do not skip doses or change the dosing schedule without talking to yourdoctor amiodarone fda warning. Missed or delayed doses could be harmful amiodarone fda warning.
• Do not consume grapefruit or grapefruit juice during treatment with amiodarone amiodarone fda warning. Amiodarone can interact with grapefruit and grapefruit juice, and the interactionmay have dangerous effects amiodarone fda warning. You should discuss the use of grapefruit and grapefruitjuice with your doctor amiodarone fda warning.
• Use caution when driving, operating machinery, or performing other hazardousactivities amiodarone fda warning. Amiodarone may cause dizziness, drowsiness, or blurred vision amiodarone fda warning. Ifyou experience dizziness, drowsiness, or blurred vision, avoid these activities amiodarone fda warning.
• Avoid prolonged exposure to sunlight amiodarone fda warning. Amiodarone may cause the skin toturn a bluish-gray color amiodarone fda warning. This reaction is worse with exposure to the sun amiodarone fda warning. Usea sunscreen and wear protective clothing when exposure to the sun is unavoidable amiodarone fda warning.


What is amiodarone?
• Amiodarone is an antiarrhythmic medication amiodarone fda warning. Amiodarone affects the waythat the heart beats amiodarone fda warning.
• Amiodarone is used to treat irregular heartbeats amiodarone fda warning.
• Amiodarone may also be used for purposes other than those listed in thismedication guide amiodarone fda warning.


What should I discuss with my healthcare provider before taking amiodarone?
• In some cases, amiodarone has been associated with serious and even fatalside effects such as lung problems, liver problems, and new or worsening irregularheartbeats amiodarone fda warning. Discuss with your doctor the risks and benefits associated withthe use of amiodarone amiodarone fda warning.
• Before taking amiodarone, tell your doctor if you
· have any other type of heart disease or heart problems;
· have liver disease;
· have vision problems (especially optic neuritis);
· have thyroid problems; or
· need to have surgery amiodarone fda warning.
• You may not be able to take amiodarone, or you may require a dosage adjustmentor special monitoring during treatment if you have any of the conditions listedabove amiodarone fda warning.
• Amiodarone is in the FDA pregnancy category D amiodarone fda warning. This means that it isknown to be harmful to an unborn baby amiodarone fda warning. Do not take amiodarone without firsttalking to your doctor if you are pregnant or could become pregnant during treatment amiodarone fda warning.
• Amiodarone passes into breast milk amiodarone fda warning. It is not known whether this medicationwill affect a nursing infant amiodarone fda warning. Do not take amiodarone without first talking toyour doctor if you are breast-feeding a baby amiodarone fda warning.


How should I take amiodarone?
• Take amiodarone exactly as directed by your doctor amiodarone fda warning. If you do not understandthese directions, ask your pharmacist, nurse, or doctor to explain them to you amiodarone fda warning.
• Take each dose with a full glass of water amiodarone fda warning.
• Amiodarone can be taken with or without food amiodarone fda warning. However, it should alwaysbe taken the same way, either with or without food amiodarone fda warning.
• Do not consume grapefruit or grapefruit juice during treatment with amiodarone amiodarone fda warning. Amiodarone can interact with grapefruit and grapefruit juice, and the interactionmay have dangerous effects amiodarone fda warning. You should discuss the use of grapefruit and grapefruitjuice with your doctor amiodarone fda warning.
• It is important to take amiodarone regularly to get the most benefit amiodarone fda warning.
• Do not skip doses or change the dosing schedule without talking to yourdoctor amiodarone fda warning. Missed or delayed doses could be harmful amiodarone fda warning.
• Your doctor may want you to have blood tests or other medical evaluationsduring treatment with amiodarone to monitor progress and side effects amiodarone fda warning.
• Store amiodarone at room temperature away from moisture and heat amiodarone fda warning.


What happens if I miss a dose?
• Take the missed dose as soon as you remember amiodarone fda warning. If it is almost time forthe next dose, skip the missed dose and take only the next regularly scheduleddose amiodarone fda warning. Do not take a double dose of this medication amiodarone fda warning. A double dose could be dangerous amiodarone fda warning.


What happens if I overdose?
• Seek emergency medical attention if an overdose is suspected amiodarone fda warning.
• Symptoms of an amiodarone overdose include tiredness, dizziness, confusion,a slow heart rate, yellowing of the skin or eyes, diarrhea, abdominal pain,and worsening irregular heartbeats amiodarone fda warning.


What should I avoid while taking amiodarone?
• Do not consume grapefruit or grapefruit juice during treatment with amiodarone amiodarone fda warning. Amiodarone can interact with grapefruit and grapefruit juice, and the interactionmay have dangerous effects amiodarone fda warning. You should discuss the use of grapefruit and grapefruitjuice with your doctor amiodarone fda warning.
• Use caution when driving, operating machinery, or performing other hazardousactivities amiodarone fda warning. Amiodarone may cause dizziness, drowsiness, or blurred vision amiodarone fda warning. Ifyou experience dizziness, drowsiness, or blurred vision, avoid these activities amiodarone fda warning.
• Avoid prolonged exposure to sunlight amiodarone fda warning. Amiodarone may cause the skin toturn a bluish-gray color amiodarone fda warning. This reaction is worse with exposure to the sun amiodarone fda warning. Usea sunscreen and wear protective clothing when exposure to the sun is unavoidable amiodarone fda warning.
• Follow any other special instructions given by your doctor regardingfood, beverages, or activities (e.g., driving) amiodarone fda warning.


What are the possible side effects of amiodarone?
• If you experience any of the following serious side effects, stop takingamiodarone and seek emergency medical attention:
· an allergic reaction (difficulty breathing; closing of the throat;swelling of the lips, tongue, or face; or hives);
· a new or a worsening irregular heartbeat pattern;
· wheezing, coughing, chest pain, or chest discomfort;
· yellowing of the skin or eyes;
· changes in vision, blurred vision, or decreased vision;
· cough or shortness of breath;
· fainting;
· tremor or involuntary movements; or
· skin rash;
• Other, less serious side effects may also occur amiodarone fda warning. Continue to take amiodaroneand talk to your doctor if you experience
· dizziness or tiredness;
· upset stomach, vomiting, decreased appetite, or diarrhea;
· changes in taste;
· poor coordination;
· numbness, or tingling; or
· bluish-gray discoloration of the skin amiodarone fda warning.
• Side effects other than those listed here may also occur amiodarone fda warning. Talk to yourdoctor about any side effect that seems unusual or that is especially bothersome amiodarone fda warning.


What other drugs will affect amiodarone?
• Before taking amiodarone, tell your doctor if you are taking any of thefollowing medicines:
· cimetidine (Tagamet);
· cholestyramine (Questran);
· cyclosporine (Sandimmune, Neoral);
· dextromethorphan (a cough suppressant commonly used in prescriptionand over-the-counter cough medications);
· digoxin (Lanoxin, Lanoxicaps);
· fentanyl (Duragesic, Actiq);
· lidocaine (Xylocaine, others);
· methotrexate (Rheumatrex);
· rifampin (Rifadin, Rimactane);
· the herbal product St amiodarone fda warning. John's wort;
· simvastatin (Zocor);
· theophylline (Theo-Bid, Theo-Dur, Theolair, Elixophyllin, Slo-Phyllin,others);
· warfarin (Coumadin);
· a protease inhibitor such as indinavir (Crixivan), lopinavir-ritonavir(Kaletra), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Fortovase,Invirase);
· phenytoin (Dilantin), ethotoin (Peganone), or mephenytoin (Mesantoin);
· flecainide (Tambocor), procainamide (Pronestyl, Procan SR, Procanbid),quinidine (Cardioquin, Quinaglute, Quinora, Quinidex), disopyramide (Norpace),or other medicines used to treat irregular heartbeats;
· a beta-blocker such as acebutolol (Sectral), atenolol (Tenormin), metoprolol(Lopressor), propranolol (Inderal), and others; or
· a calcium channel blocker such as verapamil (Calan, Verelan, Isoptin),diltiazem (Cardizem, Dilacor XR), nifedipine (Procardia, Adalat), felodipine(Plendil), and others amiodarone fda warning.
• You may not be able to take amiodarone, or you may require a dosage adjustmentor special monitoring if you are taking any of the medicines listed above amiodarone fda warning.
• Drugs other than those listed here may also interact with amiodarone amiodarone fda warning. Talk to your doctor and pharmacist before taking any prescription or over-the-countermedicines, including vitamins, minerals, and herbal products amiodarone fda warning.


Where can I get more information?
• Your pharmacist has more information about amiodarone written for healthprofessionals that you may read amiodarone fda warning.

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