|
|
|||
|
|||
|
|
|||
|
long term antabuse cambridge company |
|||
|
|
|||
|
|||
 
|
|||
|
|
|||
|
long term antabuse cambridge company Manufacturer: Odyssey
The physician should instruct relatives accordingly long term antabuse cambridge company.
CHEMICAL NAME: bis(diethylthiocarbamoyl) disulfide long term antabuse cambridge company. STRUCTURAL FORMULA:
Each tablet for oral administration contains 250 mg or 500 mg disulfiram, USP long term antabuse cambridge company. Tablets also contain colloidal silicon dioxide, anhydrous lactose, magnesiumstearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid long term antabuse cambridge company.
Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage long term antabuse cambridge company. Duringalcohol metabolism following disulfiram intake, the concentration of acetaldehydeoccurring in the blood may be 5 to 10 times higher than that found during metabolismof the same amount of alcohol alone long term antabuse cambridge company. Accumulation of acetaldehyde in the blood produces a complex of highly unpleasantsymptoms referred to hereinafter as the disulfiram-alcohol reaction long term antabuse cambridge company. This reaction,which is proportional to the dosage of both disulfiram and alcohol, will persistas long as alcohol is being metabolized long term antabuse cambridge company. Disulfiram does not appear to influencethe rate of alcohol elimination from the body long term antabuse cambridge company. Disulfiram is absorbed slowly from the gastrointestinal tract and is eliminatedslowly from the body long term antabuse cambridge company. One (or even two) weeks after a patient has taken hislast dose of disulfiram, ingestion of alcohol may produce unpleasant symptoms long term antabuse cambridge company. Prolonged administration of disulfiram does not produce tolerance; the longera patient remains on therapy, the more exquisitely sensitive he becomes to alcohol long term antabuse cambridge company.
Disulfiram is not a cure for alcoholism long term antabuse cambridge company. When used alone, without proper motivationand supportive therapy, it is unlikely that it will have any substantive effecton the drinking pattern of the chronic alcoholic long term antabuse cambridge company.
Disulfiram is contraindicated in the presence of severe myocardial diseaseor coronary occlusion, psychoses, and hypersensitivity to disulfiram or to otherthiuram derivatives used in pesticides and rubber vulcanization long term antabuse cambridge company.
The physician should instruct relatives accordingly long term antabuse cambridge company. The patient must be fully informed of the disulfiram-alcohol reaction long term antabuse cambridge company. He mustbe strongly cautioned against surreptitious drinking while taking the drug,and he must be fully aware of the possible consequences long term antabuse cambridge company. He should be warnedto avoid alcohol in disguised forms, i.e., in sauces, vinegars, cough mixtures,and even in aftershave lotions and back rubs long term antabuse cambridge company. He should also be warned thatreactions may occur with alcohol up to 14 days after ingesting disulfiram long term antabuse cambridge company. The Disulfiram-Alcohol Reaction: Disulfiram plus alcohol, even small amounts,produce flushing, throbbing in head and neck, throbbing headache, respiratorydifficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation,dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness,weakness, vertigo, blurred vision, and confusion long term antabuse cambridge company. In severe reactions theremay be respiratory depression, cardiovascular collapse, arrhythmias, myocardialinfarction, acute congestive heart failure, unconsciousness, convulsions, anddeath long term antabuse cambridge company. The intensity of the reaction varies with each individual, but is generallyproportional to the amounts of disulfiram and alcohol ingested long term antabuse cambridge company. Mild reactionsmay occur in the sensitive individual when the blood alcohol concentration isincreased to as little as 5 to 10 mg per 100 mL long term antabuse cambridge company. Symptoms are fully developedat 50 mg per 100 mL, and unconsciousness usually results when the blood alcohollevel reaches 125 to 150 mg long term antabuse cambridge company. The duration of the reaction varies from 30 to 60 minutes, to several hoursin the more severe cases, or as long as there is alcohol in the blood long term antabuse cambridge company. Concomitant Conditions: Because of the possibility of an accidental disulfiram-alcoholreaction, disulfiram should be used with extreme caution in patients with anyof the following conditions: diabetes mellitus, hypothyroidism, epilepsy, cerebraldamage, chronic and acute nephritis, hepatic cirrhosis or insufficiency long term antabuse cambridge company.
It is suggested that every patient under treatment carry an IdentificationCard stating that he is receiving disulfiram and describing the symptoms mostlikely to occur as a result of the disulfiram-alcohol reaction long term antabuse cambridge company. In addition,this card should indicate the physician or institution to be contacted in anemergency long term antabuse cambridge company. (Cards may be obtained from ODYSSEY PHARMACEUTICALS upon request.) Alcoholism may accompany or be followed by dependence on narcotics or sedatives long term antabuse cambridge company. Barbiturates and disulfiram have been administered concurrently without untowardeffects; the possibility of initiating a new abuse should be considered long term antabuse cambridge company. Hepatic toxicity including hepatic failure resulting in transplantation ordeath have been reported long term antabuse cambridge company. Severe and sometimes fatal hepatitis associated withdisulfiram therapy may develop even after many months of therapy long term antabuse cambridge company. Hepatic toxicityhas occurred in patients with or without prior history of abnormal liver function long term antabuse cambridge company. Patients should be advised to immediately notify their physician of any earlysymptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea,vomiting, jaundice, or dark urine long term antabuse cambridge company. Baseline and follow-up liver function tests (10-14 days) are suggested to detectany hepatic dysfunction that may result with disulfiram therapy long term antabuse cambridge company. In addition,a complete blood count and serum chemistries, including liver function tests,should be monitored long term antabuse cambridge company. Patients taking disulfiram tablets should not be exposed to ethylene dibromideor its vapors long term antabuse cambridge company. This precaution is based on preliminary results of animal researchcurrently in progress that suggest a toxic interaction between inhaled ethylenedibromide and ingested disulfiram resulting in a higher incidence of tumorsand mortality in rats long term antabuse cambridge company. A correlation between this finding and humans, however,has not been demonstrated long term antabuse cambridge company.
DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS RECEIVING PHENYTOINAND ITS CONGENERS, SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CANLEAD TO PHENYTOIN INTOXICATION long term antabuse cambridge company. PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENTON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED long term antabuse cambridge company. SUBSEQUENTTO INITIATION OF DISULFIRAM THERAPY, SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINEDON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS long term antabuse cambridge company. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT long term antabuse cambridge company. It may be necessary to adjust the dosage of oral anticoagulants upon beginningor stopping disulfiram, since disulfiram may prolong prothrombin time long term antabuse cambridge company. Patients taking isoniazid when disulfiram is given should be observed for theappearance of unsteady gait or marked changes in mental status, the disulfiramshould be discontinued if such signs appear long term antabuse cambridge company. In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78weeks has been reported to cause tumors, and it has been suggested that disulfirammay react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic long term antabuse cambridge company. Disulfiram alone in the rat's diet did not lead to such tumors long term antabuse cambridge company. The relevanceof this finding to humans is not known at this time long term antabuse cambridge company. Usage in Pregnancy: The safe use of this drug in pregnancy has not been established long term antabuse cambridge company. Therefore, disulfiram should be used during pregnancy only when, in the judgementof the physician, the probable benefits outweigh the possible risks long term antabuse cambridge company. Pediatric Use: Safety and effectiveness in pediatric patients have not beenestablished long term antabuse cambridge company. Nursing Mothers: It is not known whether this drug is excreted in human milk long term antabuse cambridge company. Since many drugs are so excreted, disulfiram should not be given to nursingmothers long term antabuse cambridge company. Geriatric Use: A determination has not been made whether controlled clinicalstudies of disulfiram included sufficient numbers of subjects aged 65 and overto define a difference in response from younger subjects long term antabuse cambridge company. Other reported clinicalexperience has not identified differences in responses between the elderly andyounger patients long term antabuse cambridge company. In general, dose selection for an elderly patient should becautious, usually starting at the low end of the dosing range, reflecting thegreater frequency of decreased hepatic, renal or cardiac function, and of concomitantdisease or other drug therapy long term antabuse cambridge company. |
|||
 
|
|||
|
|
|||
|
|
|||
|
|
|||
|
|
|||
|
|
|||
| llong term antabuse cambridge company loong term antabuse cambridge company lonng term antabuse cambridge company longg term antabuse cambridge company long term antabuse cambridge company long tterm antabuse cambridge company long teerm antabuse cambridge company long terrm antabuse cambridge company long termm antabuse cambridge company long term antabuse cambridge company long term aantabuse cambridge company long term anntabuse cambridge company long term anttabuse cambridge company long term antaabuse cambridge company long term antabbuse cambridge company long term antabuuse cambridge company long term antabusse cambridge company long term antabusee cambridge company long term antabuse cambridge company long term antabuse ccambridge company long term antabuse caambridge company long term antabuse cammbridge company long term antabuse cambbridge company long term antabuse cambrridge company long term antabuse cambriidge company long term antabuse cambriddge company long term antabuse cambridgge company long term antabuse cambridgee company long term antabuse cambridge company long term antabuse cambridge ccompany long term antabuse cambridge coompany long term antabuse cambridge commpany long term antabuse cambridge comppany long term antabuse cambridge compaany long term antabuse cambridge companny long term antabuse cambridge companyy ong term antabuse cambridge company lng term antabuse cambridge company log term antabuse cambridge company lon term antabuse cambridge company longterm antabuse cambridge company long erm antabuse cambridge company long trm antabuse cambridge company long tem antabuse cambridge company long ter antabuse cambridge company long termantabuse cambridge company long term ntabuse cambridge company long term atabuse cambridge company long term anabuse cambridge company long term antbuse cambridge company long term antause cambridge company long term antabse cambridge company long term antabue cambridge company long term antabus cambridge company long term antabusecambridge company long term antabuse ambridge company long term antabuse cmbridge company long term antabuse cabridge company long term antabuse camridge company long term antabuse cambidge company long term antabuse cambrdge company long term antabuse cambrige company long term antabuse cambride company long term antabuse cambridg company long term antabuse cambridgecompany long term antabuse cambridge ompany long term antabuse cambridge cmpany long term antabuse cambridge copany long term antabuse cambridge comany long term antabuse cambridge compny long term antabuse cambridge compay long term antabuse cambridge compan l ong term antabuse cambridge company lo ng term antabuse cambridge company lon g term antabuse cambridge company long term antabuse cambridge company long term antabuse cambridge company long t erm antabuse cambridge company long te rm antabuse cambridge company long ter m antabuse cambridge company long term antabuse cambridge company long term antabuse cambridge company long term a ntabuse cambridge company long term an tabuse cambridge company long term ant abuse cambridge company long term anta buse cambridge company long term antab use cambridge company long term antabu se cambridge company long term antabus e cambridge company long term antabuse cambridge company long term antabuse cambridge company long term antabuse c ambridge company long term antabuse ca mbridge company long term antabuse cam bridge company long term antabuse camb ridge company long term antabuse cambr idge company long term antabuse cambri dge company long term antabuse cambrid ge company long term antabuse cambridg e company long term antabuse cambridge company long term antabuse cambridge company long term antabuse cambridge c ompany long term antabuse cambridge co mpany long term antabuse cambridge com pany long term antabuse cambridge comp any long term antabuse cambridge compa ny long term antabuse cambridge compan y long term antabuse cambridge company olng term antabuse cambridge company lnog term antabuse cambridge company logn term antabuse cambridge company lon gterm antabuse cambridge company longt erm antabuse cambridge company long etrm antabuse cambridge company long trem antabuse cambridge company long temr antabuse cambridge company long ter mantabuse cambridge company long terma ntabuse cambridge company long term natabuse cambridge company long term atnabuse cambridge company long term anatbuse cambridge company long term antbause cambridge company long term antaubse cambridge company long term antabsue cambridge company long term antabues cambridge company long term antabus ecambridge company long term antabusec ambridge company long term antabuse acmbridge company long term antabuse cmabridge company long term antabuse cabmridge company long term antabuse camrbidge company long term antabuse cambirdge company long term antabuse cambrdige company long term antabuse cambrigde company long term antabuse cambrideg company long term antabuse cambridg ecompany long term antabuse cambridgec ompany long term antabuse cambridge ocmpany long term antabuse cambridge cmopany long term antabuse cambridge copmany long term antabuse cambridge comapny long term antabuse cambridge compnay long term antabuse cambridge compayn along term antabuse cambridge company thelong term antabuse cambridge company long term antabuse cambridge company | |||
|
|
|||
|
|
|||
|
|
|||
|
Copyright 2005 D-S LTD. |
